Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2016 Sep 1;26(17):4382-5. doi: 10.1016/j.bmcl.2015.06.038. Epub 2015 Jun 25.

Isolation of three new annonaceous acetogenins from Graviola fruit (Annona muricata) and their anti-proliferation on human prostate cancer cell PC-3.

Author information

1
Department of Nutrition and Food Science, Wayne State University, 5045 Cass Ave, Detroit, MI 48202, United States.
2
Barbara Ann Karmanos Cancer Institute and Departments of Oncology, Pharmacology and Pathology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
3
Department of Nutrition and Food Science, Wayne State University, 5045 Cass Ave, Detroit, MI 48202, United States. Electronic address: kzhou@wayne.edu.

Abstract

Bioassay-guided fractionation of the fruit powder of Graviola (Annona muricata) was continued to be conducted and yielded three more novel bioactive compounds: C-35 annonaceous acetogenins, muricins M and N, and C-37 annonaceous acetogenins, muricenin. They all contain a mono-tetrahydrofuran ring and four hydroxyl groups. The structures were elucidated by spectral methods and chemical modification after isolation via open column chromatographic separation and HPLC purification. Especially, murices M and N demonstrated more potent anti-proliferative activities against human prostate cancer PC-3 cells.

KEYWORDS:

Acetogenin; Annona muricata; Human prostate cancer PC-3 cells; Muricin

PMID:
27499453
DOI:
10.1016/j.bmcl.2015.06.038
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center