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Prostaglandins Leukot Essent Fatty Acids. 2016 Aug;111:8-10. doi: 10.1016/j.plefa.2016.05.008. Epub 2016 May 13.

Docosahexaenoic acid supplementation (DHA) and the return on investment for pregnancy outcomes.

Author information

1
The Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
2
The Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA.
3
The Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.
4
The Department of Psychology, University of Kansas, Lawrence, KS, USA.
5
The Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: scarlson@kumc.edu.

Abstract

The Kansas University DHA Outcomes Study (KUDOS) found a significant reduction in early preterm births with a supplement of 600mg DHA per day compared to placebo. The objective of this analysis was to determine if hospital costs differed between groups. We applied a post-hoc cost analysis of the delivery hospitalization and all hospitalizations in the following year to 197 mother-infant dyads who delivered at Kansas University Hospital. Hospital cost saving of DHA supplementation amounted to $1678 per infant. Even after adjusting for the estimated cost of providing 600mg/d DHA for 26 weeks ($166.48) and a slightly higher maternal care cost ($26) in the DHA group, the net saving per dyad was $1484. Extrapolating this to the nearly 4 million US deliveries per year suggests universal supplementation with 600mg/d during the last 2 trimesters of pregnancy could save the US health care system up to USD 6 billion.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00266825.

KEYWORDS:

Docosahexaenoic acid; Hospital cost; Pregnancy; Preterm birth

PMID:
27499448
PMCID:
PMC4978141
DOI:
10.1016/j.plefa.2016.05.008
[Indexed for MEDLINE]
Free PMC Article

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