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Neurochem Int. 2017 Jun;106:101-107. doi: 10.1016/j.neuint.2016.08.001. Epub 2016 Aug 3.

Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?

Author information

1
Institute of Infection, Inflammation and Immunity, Glial Cell Biology Group, Sir Graeme Davies Building, Room B329, 120 University Place, University of Glasgow, Glasgow, G12 8TA, United Kingdom.
2
Institute of Infection, Inflammation and Immunity, Glial Cell Biology Group, Sir Graeme Davies Building, Room B329, 120 University Place, University of Glasgow, Glasgow, G12 8TA, United Kingdom. Electronic address: Susan.Barnett@Glasgow.ac.uk.

Abstract

In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differentiation capabilities. Presently there is a great deal of interest in stem cells isolated from both embryonic and adult tissues in the hope they hold the therapeutic key to restoring or treating damaged cells in a number of central nervous system (CNS) disorders. In this review we will discuss the role of mesenchymal stromal cells (MSCs) isolated from human olfactory mucosa, with particular emphasis on their potential role as a candidate for transplant mediated repair in the CNS. Since nestin expression defines the entire population of olfactory mucosal derived MSCs, we will compare these cells to a population of neural crest derived nestin positive population of bone marrow-MSCs.

KEYWORDS:

Bone marrow; Human mesenchymal stromal cells; Myelination; Nestin; Olfactory mucosa

PMID:
27498150
PMCID:
PMC5455984
DOI:
10.1016/j.neuint.2016.08.001
[Indexed for MEDLINE]
Free PMC Article

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