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Neuron. 2016 Aug 3;91(3):644-51. doi: 10.1016/j.neuron.2016.06.036.

Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits.

Author information

1
Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; University of Basel, 4000 Basel, Switzerland.
2
Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
3
Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; University of Basel, 4000 Basel, Switzerland. Electronic address: andreas.luthi@fmi.ch.

Abstract

Cannabinoid receptor type 1 (CB1R)-expressing CCK interneurons are key regulators of cortical circuits. Here we report that retrograde endocannabinoid signaling and CB1R-mediated regulation of inhibitory synaptic transmission onto basal amygdala principal neurons strongly depend on principal neuron projection target. Projection-specific asymmetries in the regulation of local inhibitory micro-circuits may contribute to the selective activation of distinct amygdala output pathways during behavioral changes.

PMID:
27497223
DOI:
10.1016/j.neuron.2016.06.036
[Indexed for MEDLINE]
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