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Curr Opin Microbiol. 2016 Dec;34:18-23. doi: 10.1016/j.mib.2016.07.014. Epub 2016 Aug 4.

Cell division of Streptococcus pneumoniae: think positive!

Author information

1
CNRS, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France; Université Lyon 1, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France; Univ Lyon, Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, 43 bd du 11 novembre 1918, F-69622 Villeurbanne, France.
2
Université Grenoble Alpes, Institut de Biologie Structurale, 71 avenue des Martyrs - CS10090, 38044 Grenoble cedex 9, France; CEA, DSV, Institut de Biologie Structurale, 71 avenue des Martyrs - CS10090, 38044 Grenoble cedex 9, France; CNRS, Institut de Biologie Structurale, 71 avenue des Martyrs - CS10090, 38044 Grenoble cedex 9, France.
3
Univ Lyon, Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, 43 bd du 11 novembre 1918, F-69622 Villeurbanne, France.
4
CNRS, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France; Université Lyon 1, Molecular Microbiology and Structural Biochemistry, UMR 5086, 7 passage du Vercors, 69367 Lyon, France. Electronic address: c.grangeasse@ibcp.fr.

Abstract

Bacterial cell division is achieved by a dynamic protein complex called the divisome. The accurate placement of the divisome, and more specifically that of the tubulin-like protein FtsZ which forms the contractile Z-ring at mid-cell, is finely regulated by different mechanisms tailored to each bacterial class. To give rise to two viable daughter cells with the same genetic heritage and cell shape, Streptococcus pneumoniae uses an original system that relies on the membrane protein MapZ. This system is required for identifying the division site as well as positioning the Z-ring at mid-cell. In addition, MapZ undergoes phosphorylation by the serine/threonine kinase StkP and controls the constriction of the Z-ring. Here, we discuss recent advances and concepts of the MapZ system.

PMID:
27497051
DOI:
10.1016/j.mib.2016.07.014
[Indexed for MEDLINE]

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