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Reprod Toxicol. 2017 Mar;68:130-144. doi: 10.1016/j.reprotox.2016.07.020. Epub 2016 Aug 2.

Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice.

Author information

1
Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States. Electronic address: Beverly.rubin@tufts.edu.
2
Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA 02111, United States.
3
Nutrition and Genomics Lab., Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
4
Obesity and Metabolism Lab., Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.

Abstract

Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response.

KEYWORDS:

Bisphenol A (BPA); Body composition; Developmental origins of adult disease; Extreme hyperactivity; Non-monotonic dose response; Obesity; Sex differences

PMID:
27496714
PMCID:
PMC5531762
DOI:
10.1016/j.reprotox.2016.07.020
[Indexed for MEDLINE]
Free PMC Article

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