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NMR Biomed. 2016 Oct;29(10):1373-80. doi: 10.1002/nbm.3579. Epub 2016 Aug 5.

Fast volumetric imaging of bound and pore water in cortical bone using three-dimensional ultrashort-TE (UTE) and inversion recovery UTE sequences.

Author information

1
Department of Orthopedics, Peking Union Medical College Hospital, Beijing, China.
2
Department of Radiology, University of California, San Diego, CA, USA.
3
Applied Science Laboratory, GE Healthcare, San Diego, CA, USA.
4
Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA.
5
Department of Radiology, University of California, San Diego, CA, USA. jiangdu@ucsd.edu.

Abstract

We report the three-dimensional ultrashort-TE (3D UTE) and adiabatic inversion recovery UTE (IR-UTE) sequences employing a radial trajectory with conical view ordering for bi-component T2 * analysis of bound water (T2 *(BW) ) and pore water (T2 *(PW) ) in cortical bone. An interleaved dual-echo 3D UTE acquisition scheme was developed for fast bi-component analysis of bound and pore water in cortical bone. A 3D IR-UTE acquisition scheme employing multiple spokes per IR was developed for bound water imaging. Two-dimensional UTE (2D UTE) and IR-UTE sequences were employed for comparison. The sequences were applied to bovine bone samples (n = 6) and volunteers (n = 6) using a 3-T scanner. Bi-component fitting of 3D UTE images of bovine samples showed a mean T2 *(BW) of 0.26 ± 0.04 ms and T2 *(PW) of 4.16 ± 0.35 ms, with fractions of 21.5 ± 3.6% and 78.5 ± 3.6%, respectively. The 3D IR-UTE signal showed a single-component decay with a mean T2 *(BW) of 0.29 ± 0.05 ms, suggesting selective imaging of bound water. Similar results were achieved with the 2D UTE and IR-UTE sequences. Bi-component fitting of 3D UTE images of the tibial midshafts of healthy volunteers showed a mean T2 *(BW) of 0.32 ± 0.08 ms and T2 *(PW) of 5.78 ± 1.24 ms, with fractions of 34.2 ± 7.4% and 65.8 ± 7.4%, respectively. Single-component fitting of 3D IR-UTE images showed a mean T2 *(BW) of 0.35 ± 0.09 ms. The 3D UTE and 3D IR-UTE techniques allow fast volumetric mapping of bound and pore water in cortical bone.

KEYWORDS:

IR-UTE; T2*; UTE; bone; bound water; cones; pore water

PMID:
27496335
PMCID:
PMC5035210
DOI:
10.1002/nbm.3579
[Indexed for MEDLINE]
Free PMC Article

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