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Clin Chim Acta. 2016 Oct 1;461:110-3. doi: 10.1016/j.cca.2016.08.002. Epub 2016 Aug 2.

Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men.

Author information

1
Heart Institute, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
2
Department of Pharmacology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, Sao Paulo, Brazil.
3
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, Universidade de Sao Paulo (FMRP-USP), Ribeirao Preto, Sao Paulo, Brazil.
4
Department of Pharmacology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, Sao Paulo, Brazil. Electronic address: valeria.sandrim@ibb.unesp.br.

Abstract

BACKGROUND:

Several evidences report that a vegetarian diet is protector against cardiovascular diseases. Few studies have demonstrated the circulating profile of cardiovascular biomarkers in vegetarians. Therefore, the aims of the current study were compared the plasma concentrations of myeloperoxidase (MPO), metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 between healthy vegetarian (Veg) and healthy omnivorous (Omn).

METHODS:

Using ELISA and multiplexed bead immunoassay, we measured in plasma from 43 Veg and 41 Omn the cardiovascular biomarkers concentrations cited above.

RESULTS:

We found significant lower concentrations of MPO, MMP-9, MMP-2 and MMP-9/TIMP-1 ratio in Veg compared to Omn (all P<0.05). Moreover, MMP-9 concentrations were correlated positively with leukocytes and neutrophils count in both groups (all P<0.05).

CONCLUSION:

A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous.

KEYWORDS:

Cardiovascular biomarkers; MMP-2; MMP-9; MPO; Omnivorous; TIMP; Vegetarians

PMID:
27496081
DOI:
10.1016/j.cca.2016.08.002
[Indexed for MEDLINE]

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