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Transpl Infect Dis. 2016 Oct;18(5):801-804. doi: 10.1111/tid.12585. Epub 2016 Sep 16.

Visceral leishmaniasis in a lung transplant recipient: usefulness of highly sensitive real-time polymerase chain reaction for preemptive diagnosis.

Author information

1
Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland.
2
Pneumology Service, University Hospital of Lausanne, Lausanne, Switzerland.
3
Transplantation Center, University Hospital and University of Lausanne, Lausanne, Switzerland.
4
Hematology Service, University Hospital and University of Lausanne, Lausanne, Switzerland.
5
Infectious Diseases Service, University Hospital of Lausanne, Lausanne, Switzerland.
6
Transplantation Center, University Hospital and University of Lausanne, Lausanne, Switzerland. oriol.manuel@chuv.ch.
7
Infectious Diseases Service, University Hospital of Lausanne, Lausanne, Switzerland. oriol.manuel@chuv.ch.

Abstract

We report the case of a lung transplant recipient in whom the diagnosis of visceral leishmaniasis (VL) was made by detection of parasites in a peripheral blood smear when the parasite load already reached 8.9 × 103 parasites/mL. We demonstrated that the VL diagnosis could have been done months before the development of symptoms by the use of Leishmania-specific real-time polymerase chain reaction (PCR), suggesting the role of preemptive PCR-based diagnosis in transplant recipients at risk for VL.

KEYWORDS:

kinetoplastic DNA; leishmaniasis; lung transplant; preemptive diagnosis; real-time polymerase chain reaction; solid organ transplant

PMID:
27495987
DOI:
10.1111/tid.12585
[Indexed for MEDLINE]
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