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Oncotarget. 2016 Dec 13;7(50):82338-82353. doi: 10.18632/oncotarget.11001.

MicroRNA-891b is an independent prognostic factor of pancreatic cancer by targeting Cbl-b to suppress the growth of pancreatic cancer cells.

Author information

1
Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
2
Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, 110001, China.
3
Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
4
Department of Medical Oncology, The Liaoning Provincial Tumor Hospital, Shenyang, 110042, China.

Abstract

Growing evidence has revealed that microRNAs could regulate the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and predict the prognosis of PDAC. Here the comparative microRNA expression profiles of the good and poor prognosis groups were performed by microRNA microarray. MicroRNA-891b (miR-891b) was screened and validated to be a prognostic predictor of PDAC in the initial group and further evaluated to be an independent predictor for the overall survival of resectable PDACs in an independent cohort. By a series of cellular and animal experiments, as well as clinical specimen analyses, miR-891b was confirmed to target the Cbl-b gene, promot the expression of tumor suppressor p21 protein and inhibit the proliferation of PDAC cells. The results provide a theoretical basis for the study of miR-891b as an independent prognostic predictor of PDAC and the role of miR-891b/Cbl-b pathway in this prediction, as well as the identification of new targets for PDAC.

KEYWORDS:

Cbl-b; microRNA-891b (miR-891b); overall survival (OS); pancreatic ductal adenocarcinoma (PDAC); prognosis

PMID:
27494897
PMCID:
PMC5347695
DOI:
10.18632/oncotarget.11001
[Indexed for MEDLINE]
Free PMC Article

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