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PLoS Biol. 2016 Aug 5;14(8):e1002528. doi: 10.1371/journal.pbio.1002528. eCollection 2016 Aug.

The Temporal Signature of Memories: Identification of a General Mechanism for Dynamic Memory Replay in Humans.

Author information

1
School of Psychology, University of Birmingham, Birmingham, United Kingdom.
2
School of Computing, University of Kent, Canterbury, United Kingdom.

Abstract

Reinstatement of dynamic memories requires the replay of neural patterns that unfold over time in a similar manner as during perception. However, little is known about the mechanisms that guide such a temporally structured replay in humans, because previous studies used either unsuitable methods or paradigms to address this question. Here, we overcome these limitations by developing a new analysis method to detect the replay of temporal patterns in a paradigm that requires participants to mentally replay short sound or video clips. We show that memory reinstatement is accompanied by a decrease of low-frequency (8 Hz) power, which carries a temporal phase signature of the replayed stimulus. These replay effects were evident in the visual as well as in the auditory domain and were localized to sensory-specific regions. These results suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory replay in humans.

PMID:
27494601
PMCID:
PMC4975452
DOI:
10.1371/journal.pbio.1002528
[Indexed for MEDLINE]
Free PMC Article

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