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Surg Neurol. 1989 Aug;32(2):144-51.

Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon.

Author information

1
Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.

Abstract

Eight cases of carbamazepine toxicity from interaction with propoxyphene are reported. Serum concentrations of carbamazepine increased up to sixfold. All patients were symptomatic and two were hospitalized. Practitioners prescribing propoxyphene acutely for pain should be aware of this significant interaction.

PMID:
2749458
[Indexed for MEDLINE]

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