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Nat Rev Cancer. 2016 Oct;16(10):619-34. doi: 10.1038/nrc.2016.71. Epub 2016 Jul 29.

From Krebs to clinic: glutamine metabolism to cancer therapy.

Altman BJ1,2,3, Stine ZE1,2,3, Dang CV1,2,3.

Author information

1
Abramson Family Cancer Research Institute, University of Pennsylvania.
2
Abramson Cancer Center, University of Pennsylvania.
3
Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

PMID:
27492215
PMCID:
PMC5484415
DOI:
10.1038/nrc.2016.71
[Indexed for MEDLINE]
Free PMC Article

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