Format

Send to

Choose Destination
Brain Res Bull. 2016 Sep;126(Pt 3):300-310. doi: 10.1016/j.brainresbull.2016.07.013. Epub 2016 Aug 1.

Actin filament-microtubule interactions in axon initiation and branching.

Author information

1
Temple University, Lewis Kats School of Medicine, Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, 3500 North Broad Street, Philadelphia, PA 19140, United States.
2
Temple University, Lewis Kats School of Medicine, Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, 3500 North Broad Street, Philadelphia, PA 19140, United States. Electronic address: tue86088@temple.edu.

Abstract

Neurons begin life as spherical cells. A major hallmark of neuronal development is the formation of elongating processes from the cell body which subsequently differentiate into dendrites and the axon. The formation and later development of neuronal processes is achieved through the concerted organization of actin filaments and microtubules. Here, we review the literature regarding recent advances in the understanding of cytoskeletal interactions in neurons focusing on the initiation of processes from neuronal cell bodies and the collateral branching of axons. The complex crosstalk between cytoskeletal elements is mediated by a cohort of proteins that either bind both cytoskeletal systems or allow one to regulate the other. Recent studies have highlighted the importance of microtubule plus-tip proteins in the regulation of the dynamics and organization of actin filaments, while also providing a mechanism for the subcellular capture and guidance of microtubule tips by actin filaments. Although the understanding of cytoskeletal crosstalk and interactions in neuronal morphogenesis has advanced significantly in recent years the appreciation of the neuron as an integrated cytoskeletal system remains a frontier.

KEYWORDS:

Axon sprouting; F-actin; Filopodia; Growth cone; Lamellipodia; Microtubule associated proteins; Microtubule dynamics; Plus tips

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center