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Trends Plant Sci. 2016 Nov;21(11):962-973. doi: 10.1016/j.tplants.2016.07.005. Epub 2016 Aug 2.

The Unexpected Diversity of Plant Organelle RNA Editosomes.

Author information

1
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
2
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. Electronic address: mrh5@cornell.edu.

Abstract

Flowering plants convert many hundreds of organelle cytidines (Cs) to uridines (Us) during post-transcriptional RNA editing. Pentatricopeptide repeat (PPR) proteins dictate specificity by recognizing RNA sequences near C targets. However, the complete mechanism of the editing machinery is not yet understood. Recently, non-PPR editing factors [RNA editing factor interacting proteins (RIPs)/multiple organellar RNA editing factors (MORFs), organelle RNA recognition motif (ORRM) proteins, organelle zinc-finger (OZ) proteins, and protoporphyrinogen oxidase 1 (PPO1)] have been identified as components of the plant RNA editosome, which is a small RNA-protein complex. Surprisingly, plant editosomes are highly diverse not only with regard to the PPR proteins they contain but also in the non-PPR components that are present. Here we review the most recent progress in the field and discuss the implications of the diversity of plant editosomes for the evolution of RNA editing and for possible future applications.

KEYWORDS:

RNA recognition motif; chloroplasts; mitochondria; pentatricopeptide; protein complex; zinc-finger motif.

PMID:
27491516
DOI:
10.1016/j.tplants.2016.07.005
[Indexed for MEDLINE]

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