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Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S140-5. doi: 10.1097/PCC.0000000000000754.

Pulmonary Hypertension.

Author information

1
Both authors: Division of Critical Care Medicine, Department of Pediatrics, University of California San Francisco School of Medicine, University of California San Francisco Benioff Children's Hospital, San Francisco, CA.

Abstract

OBJECTIVES:

To review the clinical classification, diagnosis, and pathophysiology of pulmonary hypertension in children, emphasizing the role of right ventricular function, ventricular interaction, and congenital heart disease in the evolution and progression of disease, as well as management strategies and therapeutic options.

DATA SOURCE:

MEDLINE, PubMed.

CONCLUSIONS:

Critically ill children with pulmonary hypertension associated with congenital heart disease are a high-risk population. Congenital cardiac defects resulting in either increased pulmonary blood flow or impaired pulmonary venous drainage predispose patients to developing structural and functional aberrations of the pulmonary vasculature. Mortality from pulmonary hypertension is most directly related to right ventricular failure.

PMID:
27490592
PMCID:
PMC4975433
DOI:
10.1097/PCC.0000000000000754
[Indexed for MEDLINE]
Free PMC Article

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