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Transplantation. 2016 Nov;100(11):2288-2300. doi: 10.1097/TP.0000000000001379.

Impact of Immune-Modulatory Drugs on Regulatory T Cell.

Author information

1
Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
#
Contributed equally

Abstract

Immunosuppression strategies that selectively inhibit effector T cells while preserving and even enhancing CD4FOXP3 regulatory T cells (Treg) permit immune self-regulation and may allow minimization of immunosuppression and associated toxicities. Many immunosuppressive drugs were developed before the identity and function of Treg were appreciated. A good understanding of the interactions between Treg and immunosuppressive agents will be valuable to the effective design of more tolerable immunosuppression regimens. This review will discuss preclinical and clinical evidence regarding the influence of current and emerging immunosuppressive drugs on Treg homeostasis, stability, and function as a guideline for the selection and development of Treg-friendly immunosuppressive regimens.

PMID:
27490409
PMCID:
PMC5077666
DOI:
10.1097/TP.0000000000001379
[Indexed for MEDLINE]
Free PMC Article

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