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Res Commun Chem Pathol Pharmacol. 1989 Apr;64(1):69-78.

Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1.

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Division of Clinical Pharmacology, Tokyo College of Pharmacy, Japan.


An examination was made of the effects of 21 synthetic and naturally occurring flavonoids on the in vitro growth of cells of the human breast carcinoma, ZR-75-1. In all cases, antiproliferative effects were noted, with an IC50 ranging from 2.7 to 33.5 micrograms/ml, except for the isoflavonoid, daidzin (IC50 greater than 50 micrograms/ml). No significant structure-activity relationship among the compounds could be found. Flavone, 6-hydroxyflavone and 4',5,7-trihydroxyflavone (apigenin) were the most potent with IC50 of 2.7, 3.4, and 3.5 micrograms/ml, respectively. The flavonoid effects observed here were not due to cytostatic action alone, since cell death was found to increase dose-dependently, according to the results of a dye exclusion test.

[Indexed for MEDLINE]

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