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Alzheimers Dement (Amst). 2016 Apr 7;4:18-27. doi: 10.1016/j.dadm.2016.03.001. eCollection 2016.

White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration.

Author information

1
Penn Image Computing and Science Laboratory and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
2
Penn Image Computing and Science Laboratory and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
3
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
4
Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA.

Abstract

INTRODUCTION:

Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and cognitive tests.

METHODS:

Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 158) underwent florbetapir-PET scans, psychometric testing, neuroimaging with MRI and PET, and APOE genetic testing. Elderly controls the Parkinson's progression markers initiative (PPMI, n = 58) had WMH volume, cerebrospinal fluid (CSF) Aβ1-42, and APOE status measured.

RESULTS:

In the ADNI cohort, only WMH volume and APOE ε4 status were associated with cerebral Aβ (standardized β = 0.44 and 1.25, P = .03 and .002). The association between WMH volume and APOE ε4 status with cerebral Aβ (standardized β = 1.12 and 0.26, P = .048 and .045) was confirmed in the PPMI cohort.

DISCUSSION:

WMH volume is more highly associated with preclinical AD than other AD biomarkers.

KEYWORDS:

Aging; Alzheimer's disease; Amyloid; Leukoaraiosis; MRI; PET; Preclinical Alzheimer's disease; White matter

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