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SAGE Open Med Case Rep. 2015 Jan 19;3:2050313X14568335. doi: 10.1177/2050313X14568335. eCollection 2015.

Liver dysfunction and anti-thyroid therapy.

Author information

1
Department of Endocrinology and Diabetes, St Vincent's Hospital-Melbourne, Melbourne, VIC, Australia.
2
Endocrine Centre of Excellence, Austin Health, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
3
Department of Endocrinology and Diabetes, St Vincent's Hospital-Melbourne, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.

Abstract

Thioamides have been used in the management of hyperthyroidism for over 50 years. Liver dysfunction is a rare but important side effect associated with their use. Recently, cases of liver failure associated with propylthiouracil have prompted the Federal Drug Administration to issue a Boxed Warning to the label of propylthiouracil regarding its risk of potentially fatal liver injury and acute liver failure in adults and children. Herein, we present a case to underline the importance of recognising the similar potential for severe hepatic dysfunction with the use of other thioamides.

KEYWORDS:

Diabetes/endocrinology; carbimazole; hyperthyroidism; liver dysfunction; pharmacoepidemiology/drug safety

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