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J Int Soc Sports Nutr. 2016 Aug 2;13:32. doi: 10.1186/s12970-016-0143-x. eCollection 2016.

The NAD(+) precursor nicotinamide riboside decreases exercise performance in rats.

Author information

1
Department of Physical Education and Sport Science at Serres, Aristotle University of Thessaloniki, Agios Ioannis, Serres, 62110 Greece.
2
Intensive Care Unit, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece.
3
School of Health Sciences, Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Greece.
4
Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
5
Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.
#
Contributed equally

Abstract

BACKGROUND:

Nicotinamide adenine dinucleotide (NAD(+)) and its phosphorylated form (NADP(+)) are key molecules in ubiquitous bioenergetic and cellular signaling pathways, regulating cellular metabolism and homeostasis. Thus, supplementation with NAD(+) and NADP(+) precursors emerged as a promising strategy to gain many and multifaceted health benefits. In this proof-of-concept study, we sought to investigate whether chronic nicotinamide riboside administration (an NAD(+) precursor) affects exercise performance.

METHODS:

Eighteen Wistar rats were equally divided in two groups that received either saline vehicle or nicotinamide riboside at a dose of 300 mg/kg body weight/day for 21 days via gavage. At the end of the 21-day administration protocol, both groups performed an incremental swimming performance test.

RESULTS:

The nicotinamide riboside group showed a tendency towards worse physical performance by 35 % compared to the control group at the final 10 % load (94 ± 53 s for the nicotinamide riboside group and 145 ± 59 s for the control group; P = 0.071).

CONCLUSION:

Our results do not confirm the previously reported ergogenic effect of nicotinamide riboside. The potentially negative effect of nicotinamide riboside administration on physical performance may be attributed to the pleiotropic metabolic and redox properties of NAD(+) and NADP(+).

KEYWORDS:

Exercise; NAD+; NADP+; Nicotinamide riboside; Performance

PMID:
27489522
PMCID:
PMC4971637
DOI:
10.1186/s12970-016-0143-x
[Indexed for MEDLINE]
Free PMC Article

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