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Acta Clin Belg. 2016 Aug 4:1-3. [Epub ahead of print]

Prosopagnosia as unusual presentation of semantic dementia: a case study.

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a IRCCS Centro Neurolesi "Bonino Pulejo" , Messina , Italy.
b Department of Biomedical and Dental Sciences and Morphofunctional Imaging , University of Messina , Messina , Italy.



Semantic dementia is one of the main clinical variants of frontotemporal dementia and it is characterized by severe loss of conceptual knowledge with relative preservation of other cortical abilities.


We described a case of a patient affected by right temporal variant of frontotemporal lobar degeneration, characterized by prosopagnosia as an unusual disease onset.


The neuropsychological evaluation showed a progressive deficit in face recognition and a slow decline in language in the absence of behavioral alterations. Magnetic resonance imaging showed diffuse vascular ischemic lesions, cortical atrophy in bilateral temporal lobes, and a marked bilateral decrease hippocampal volume, mainly involving the right side.


Our findings suggest that prosopagnosia could be a predictive marker of atypical semantic dementia onset.


Frontotemporal lobar degeneration; Hippocampus atrophy; Prosopagnosia; Semantic dementia

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