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Breast J. 2016 Nov;22(6):688-691. doi: 10.1111/tbj.12661. Epub 2016 Aug 4.

Primary Noncutaneous Malignant Melanoma of the Breast.

Author information

1
Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, Ontario, Canada.
2
Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.

Abstract

Primary noncutaneous breast melanoma without an apparent skin primary lesion is uncommon. Its pathogenesis is debated with some authors believing that it is a metastatic disease from an undiscovered primary or a primary that has since completely regressed but it may be a true primary tumor arising from ectopic melanocytes. We present a case of a V600E BRAF mutation-positive primary noncutaneous breast melanoma diagnosed at an early stage in a screening mammogram as a solitary breast lesion without nodal involvement. Considerations of treatment of this rare disease are discussed.

KEYWORDS:

BRAF ; breast; malignant melanoma; noncutaneous; parenchymal; primary

PMID:
27488963
DOI:
10.1111/tbj.12661
[Indexed for MEDLINE]

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