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Saudi J Gastroenterol. 2016 Jul-Aug;22(4):294-303. doi: 10.4103/1319-3767.187603.

Transient elastography in clinical detection of liver cirrhosis: A systematic review and meta-analysis.

Author information

1
Department of Infectious Diseases, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.

Abstract

BACKGROUND/AIMS:

Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease.

PATIENTS AND METHODS:

We searched MEDLINE, Cochrane, EMBASE databases until Jan 31, 2015, using the following search terms: elastography and liver cirrhosis. Included studies assessed patients with a diagnosis of liver cirrhosis, with an index test of transient elastography, and with the reference standard being a histopathological exam by liver biopsy. Sensitivity analysis and assessment of risk of bias and publication bias were performed.

RESULTS:

Fifty-seven studies were included in the meta-analysis with a total of 10,504 patients. The pooled estimate for the sensitivity of transient elastography for detecting liver fibrosis was 81% and the specificity was 88%. The imputed diagnostic odds ratio (DOR) was 26.08 and the area under the receiver-operating characteristic (AUROC) curve was 0.931.

CONCLUSION:

Our findings indicate that transient elastography shows good sensitivity, specificity and a high accuracy for detecting liver cirrhosis. Transient elastography can be used as an additional method for the clinical diagnosis of liver fibrosis and cirrhosis.

PMID:
27488324
PMCID:
PMC4991200
DOI:
10.4103/1319-3767.187603
[Indexed for MEDLINE]
Free PMC Article

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