Forcing FAK into Transcriptional Activity

Structure. 2016 Aug 2;24(8):1223-1225. doi: 10.1016/j.str.2016.07.004.

Abstract

Focal adhesion kinase (FAK) has known signaling roles in cytoplasmic adhesion structures, but was recently shown to act as a transcriptional regulator in the nucleus. In this issue of Structure, Cardoso et al. (2016) report that mechanical forces translocate FAK to the nucleus of cardiomyocytes, and provide structural insights into how FAK interacts with the MEF2 transcription factor to control cardiac hypertrophy.

Publication types

  • Comment

MeSH terms

  • Cardiomegaly*
  • Cell Nucleus
  • Cells, Cultured
  • Focal Adhesion Protein-Tyrosine Kinases / chemistry*
  • Humans
  • Protein-Tyrosine Kinases
  • Signal Transduction

Substances

  • Protein-Tyrosine Kinases
  • Focal Adhesion Protein-Tyrosine Kinases