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ACS Appl Mater Interfaces. 2016 Aug 24;8(33):21545-54. doi: 10.1021/acsami.6b05727. Epub 2016 Aug 11.

Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide Nanoparticles.

Author information

1
Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza , Campus Río Ebro-Edificio I+D, c/Poeta Mariano Esquillor s/n, 50018 Zaragoza, Spain.
2
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , 28029 Madrid, Spain.

Abstract

The continuous synthesis of biodegradable photothermal copper sulfide nanoparticles has been carried out with the aid of a microfluidic platform. A comparative physicochemical characterization of the resulting products from the microreactor and from a conventional batch reactor has been performed. The microreactor is able to operate in a continuous manner and with a 4-fold reduction in the synthesis times compared to that of the conventional batch reactor producing nanoparticles with the same physicochemical requirements. Biodegradation subproducts obtained under simulated physiological conditions have been identified, and a complete cytotoxicological analysis on different cell lines was performed. The photothermal effect of those nanomaterials has been demonstrated in vitro as well as their ability to generate reactive oxygen species.

KEYWORDS:

CuS nanoparticles; biodegradable nanomaterial; cells viability; microfluidic synthesis; photothermal

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