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Interdiscip Toxicol. 2015 Sep;8(3):151-4. doi: 10.1515/intox-2015-0023.

Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats.

Author information

1
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
2
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Preventive Cardiovascular Care Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Department of Agriculture, Payam Noor University, Tehran, Iran.

Abstract

Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents. The results of the present study indicated that Cd administration significantly increased the serum levels of TG, TC, LDL-C, MDA and Cd with reduction in the HDL-C and GSH levels. In conclusion, evidence is presented that chronic exposure to low Cd concentration can adversely affect the lipid and lipoprotein profile via lipid peroxidation.

KEYWORDS:

cadmium; lipid; lipoprotein; oxidative stress

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