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Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10691-6. doi: 10.1002/anie.201604879. Epub 2016 Aug 3.

Template-Directed Synthesis of Porous and Protective Core-Shell Bionanoparticles.

Author information

1
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
2
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA. gassensmith@utdallas.edu.

Abstract

Metal-organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as-prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as-fabricated MOF materials. We were able to obtain discrete rod-shaped TMV@MOF core-shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core-shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell.

KEYWORDS:

bioconjugation reactions; metal-organic frameworks; nanoparticles; tobacco mosaic virus

PMID:
27485579
DOI:
10.1002/anie.201604879
[Indexed for MEDLINE]

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