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Virol Rep. 2016 Dec;6:53-60.

Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.

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Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, NY 10461.
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.
Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, 80309, USA.
Department of Pediatrics, Emory University, Atlanta, GA 30322.


The HIV-1 restriction factor SAMHD1 has the ability to negatively modulate retrotransposition of the long interspersed element 1(LINE-1). By exploring the ability of human SAMHD1 polymorphisms to inhibit LINE-1, we found that the single nucleotide polymorphism S33A present in the Korean population lose the ability to inhibit LINE-1 retrotransposition. Because SAMHD1 residue S33 is phosphorylated in human cycling and non-cycling cells, we demonstrated that SAMHD1 requires to be either phosphorylated on position 33 or to contain a bulky residue in order to inhibit LINE-1 retrotransposition. Therefore this unique mutation uncouples functions in this important restriction factor.


HIV-1; LINE-1; SAMHD1; SNPs; restrcition; retrotransposition

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