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AIDS Res Hum Retroviruses. 2017 Jan;33(1):17-18. doi: 10.1089/AID.2016.0127. Epub 2016 Sep 7.

Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana.

Author information

  • 11 Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University , Tygerberg, South Africa .
  • 22 Botswana Harvard AIDS Institute , Gaborone, Botswana .
  • 33 National Health Laboratory , Ministry of Health, Gaborone, Botswana .
  • 44 Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
  • 55 Florida International University , College of Health and Urban Affairs, Miami, Florida.
  • 66 National Health Laboratory Services (NHLS) , Tygerberg Coastal, South Africa .

Abstract

Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during estimation of HIV incidence. To improve monitoring of HIV incidence, we estimated local FRR in Botswana. A total of 1,036 specimens from individuals infected for at least 1.5-2 years were sampled between 2004 and 2009 and tested using the limiting antigen (LAg)-avidity assay using a cutoff of 1.5 normalized optical density units. The FRR was 0.97% (10/1,036; 95% confidence interval [CI] 0.46-1.77). Four samples had HIV-1 RNA >1,000 cps/ml, giving an adjusted FRR of 0.39% (4/1,036; 95% CI 0.11-0.99). A combination of LAg and HIV-1 RNA load data resulted in FRR below 1% in the Botswana population.

KEYWORDS:

HIV incidence; HIV recency; cross-sectional incidence; false recency rate; limiting antigen assay

PMID:
27481530
PMCID:
PMC5239999
[Available on 2018-01-01]
DOI:
10.1089/AID.2016.0127
[PubMed - in process]
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