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Mult Scler. 2017 Jun;23(7):1025-1030. doi: 10.1177/1352458516662726. Epub 2016 Aug 1.

Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets.

Author information

1
Department of Neurology, University Hospital Münster, Münster, Germany.
2
Department of Radiology, University Hospital Münster, Münster, Germany.

Abstract

BACKGROUND:

Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS).

OBJECTIVE:

To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts.

METHODS:

Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation.

RESULTS:

Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography.

CONCLUSIONS:

Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.

KEYWORDS:

Multiple sclerosis; TH1; TH17; innate lymphoid cell; lesion distribution; lymphoid tissue inducer

PMID:
27481205
DOI:
10.1177/1352458516662726
[Indexed for MEDLINE]

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