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Chem Biol Interact. 2016 Sep 25;257:101-9. doi: 10.1016/j.cbi.2016.07.031. Epub 2016 Jul 29.

1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells.

Author information

1
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan. Electronic address: kojima@life.osaka-cu.ac.jp.
2
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.
3
Department of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Japan.
4
Course of Human Behavioral Sciences, Graduate School of Literature and Human Sciences, Osaka City University, Osaka, Japan.

Abstract

1'-Acetoxychavicol acetate (ACA) is naturally obtained from the rhizomes and seeds of Alpinia galangal. Here, we examined the effect of ACA on learning and memory in senescence-accelerated mice prone 8 (SAMP8). In mice that were fed a control diet containing 0.02% ACA for 25 weeks, the learning ability in the Morris water maze test was significantly enhanced in comparison with mice that were fed the control diet alone. In the Y-maze test, SAMP8 mice showed decreased spontaneous alterations in comparison with senescence-accelerated resistant/1 (SAMR1) mice, a homologous control, which was improved by ACA pretreatment. Serum metabolite profiles were obtained by GC-MS analysis, and each metabolic profile was plotted on a 3D score plot. Based upon the diagram, it can be seen that the distribution areas for the three groups were completely separate. Furthermore, the contents of β-hydroxybutyric acid and palmitic acid in the serum of SAMP8-ACA mice were higher than those of SAMP8-control mice and SAMR1-control mice. We also found that SAMR1 mice did not show histological abnormalities, whereas histological damage in the CA1 region of the hippocampus in SAMP8-control mice was observed. However, SAMP8-ACA mice were observed in a similar manner as SAMR1 mice. These findings confirm that ACA increases the serum concentrations of β-hydroxybutyric acid and palmitic acid levels and thus these fuels might contribute to the maintenance of the cognitive performance of SAMP8 mice.

KEYWORDS:

1′-Acetoxychavicol acetate; Metabolite profile; Morris water maze test; Senescence-accelerated mouse prone 8 (SAMP8); Y-maze test; β-Hydroxybutyric acid

PMID:
27481192
DOI:
10.1016/j.cbi.2016.07.031
[Indexed for MEDLINE]

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