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Thyroid. 2016 Sep;26(9):1156-66. doi: 10.1089/thy.2016.0064. Epub 2016 Aug 23.

Management of Invasive Differentiated Thyroid Cancer.

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1 NHS Lothian/Edinburgh University , Edinburgh, United Kingdom .
2 Head and Neck Cancer Unit, Guy's and St Thomas' Hospital , NHS Foundation Trust, London, United Kingdom .
3 NIHR Royal Marsden Hospital and Institute of Cancer Research BRC , London, United Kingdom .
4 University of Udine School of Medicine , Udine, Italy .
5 Department of Surgery, Universidad de Oviedo , Oviedo, Spain .
6 Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center , São Paulo, Brazil .
7 Departments of Surgery and Otolaryngology - Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center , Bronx, New York.
8 Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center , New York, New York.
9 Former Director of the Department of Surgical Sciences and Chairman of the ENT Clinic at the University of Udine School of Medicine , Udine, Italy .



Invasive disease is a poor prognostic factor for patients with differentiated thyroid cancer (DTC). Uncontrolled central neck disease is a common cause of distressing death for patients presenting in this manner. Advances in assessment and management of such cases have led to significant improvements in outcome for this patient group. This article reviews the patterns of invasion and a contemporary approach to investigation and treatment of patients with invasive DTC.


Aerodigestive tract invasion is reported in around 10% of case series of DTC. Assessment should include not only clinical history and physical examination with endoscopy as indicated, but ultrasound and contrast-enhanced cross-sectional imaging. Further studies including positron emission tomography should be considered, particularly in recurrent cases that are radioactive iodine (RAI) resistant. Both the patient and the extent of disease should be carefully assessed prior to embarking on surgery. The aim of surgery is to resect all gross disease. When minimal visceral invasion is encountered early, "shave" procedures are recommended. In the setting of transmural invasion of the airway or esophagus, however, full thickness excision is required. For intermediate cases in which invasion of the viscera has penetrated the superficial layers but is not evident in the submucosa, opinion is divided. Early reports recommended an aggressive approach. More recently authors have tended to recommend less aggressive resections with postoperative adjuvant therapies. The role of external beam radiotherapy continues to evolve in DTC with support for its use in patients considered to have RAI-resistant tumors.


Patients with invasive DTC require a multidisciplinary approach to investigation and treatment. With detailed assessment, appropriate surgery, and adjuvant therapy when indicated, this patient group can expect durable control of central neck disease, despite the aggressive nature of their primary tumors.

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