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Adv Pharm Bull. 2016 Jun;6(2):243-50. doi: 10.15171/apb.2016.033. Epub 2016 Jun 30.

Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis.

Author information

1
Cardiology Department Red Cross Hospital, Athens, Greece.
2
Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
3
Internal Medicine Department, Laiko Hospital, Athens, Greece.
4
Cardiology Department, Attiko Hospital, Athens, Greece.
5
Department of Pathology, Medical School of the National University of Athens, Greece.
6
Cardiac Surgery Department, Attiko Hospital, Athens, Greece.

Abstract

PURPOSE:

Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery.

METHODS:

A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo.

RESULTS:

Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 - 0.673, P < 10(-4)). No significant heterogeneity was detected across the analyzed studies (I(2)=21.7%), and no publication bias or other small study-related bias was found.

CONCLUSION:

Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery.

KEYWORDS:

CABG; Cardiac surgery; Post-operative atrial fibrillation; Valvular surgery; Vitamin C

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