Format

Send to

Choose Destination
Clin Kidney J. 2016 Aug;9(4):624-9. doi: 10.1093/ckj/sfw051. Epub 2016 Jun 20.

Incidence and outcome of encapsulating peritoneal sclerosis.

Author information

1
Glasgow Renal and Transplant Unit , Glasgow , UK.
2
Glasgow Renal andTransplant Unit, Glasgow, UK; Scottish Renal Registry, Glasgow, UK.

Abstract

BACKGROUND:

Studies report variation in the incidence and outcomes of encapsulating peritoneal sclerosis (EPS). This study reports the incidence and outcome of EPS cases in a national cohort of peritoneal dialysis (PD) patients.

METHODS:

The incident cohort of adult patients who started PD between 1 January 2000 and 31 December 2007 in Scotland (n = 1238) was identified from the Scottish Renal Registry. All renal units in Scotland identified potential EPS cases diagnosed from 1 January 2000 to 31 December 2014, by which point all patients had a minimum of 7 years follow-up from start of PD.

RESULTS:

By 31 December 2014, 35 EPS cases were diagnosed in the 1238 patient cohort: an overall incidence of 2.8%. The incidence for subgroups with longer PD duration rises exponentially: 1.1% by 1 year, 3.4% by 3 years, 8.8% at 4 years, 9.4% at 5 years and 22.2% by 7 years. Outcomes are poor with mortality of 57.1% by 1 year after diagnosis. Survival analysis demonstrates an initial above-average survival in patients who later develop EPS, which plummets to well below average after EPS diagnosis.

CONCLUSIONS:

The incidence of EPS is reassuringly low provided PD exposure is not prolonged and this supports ongoing use of PD. However, continuing PD beyond 3 years results in an exponential rise in the risk of developing EPS and deciding whether this risk is acceptable should be made on an individual patient basis.

KEYWORDS:

EPS; encapsulating peritoneal sclerosis; incidence; peritoneal dialysis

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center