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Neuropsychiatr Dis Treat. 2016 Jul 14;12:1747-60. doi: 10.2147/NDT.S113037. eCollection 2016.

Zika virus challenges for neuropsychiatry.

Author information

  • 1Interdisciplinary Laboratory of Medical Investigation; Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • 2Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • 3Interdisciplinary Laboratory of Medical Investigation; Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Abstract

Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain-Barré syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations.

KEYWORDS:

Guillain-Barré syndrome; Zika virus; microcephaly; neurodevelopmental disorders

PMID:
27478378
PMCID:
PMC4951060
DOI:
10.2147/NDT.S113037

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