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J Korean Med Sci. 2016 Aug;31(8):1246-53. doi: 10.3346/jkms.2016.31.8.1246. Epub 2016 May 16.

Online Registry for Nationwide Database of Current Trend of Helicobacter pylori Eradication in Korea: Interim Analysis.

Author information

1
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea .
2
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea .
3
Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea .
4
Department of Internal Medicine, Cheonan Hospital, Soon Chun Hyang University College of Medicine, Cheonan, Korea .
5
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea .
6
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Incheon, Korea .
7
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea .
8
Department of Internal Medicine, Kyungpook National University Medical Center, Daegu, Korea .
9
Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea .
10
Department of Internal Medicine, Dongguk University College of Medicine Gyeongju Hospital, Gyeongju, Korea .
11
Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine, Busan, Korea .
12
Department of Gastroenterolgy, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea .
13
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea .
14
Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea .
15
Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea .
16
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea .
17
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.; Cancer Research Institute, Seoul National University, Seoul, Korea.
18
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea .
19
Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea .

Abstract

Eradication of Helicobacter pylori using first-line therapy is becoming less effective. Subjects who had been treated for H. pylori infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for H. pylori infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant medication, and comorbidity. Regional differences in eradication rates were observed. The most common first-line therapy was proton pump inhibitor-based triple therapy (standard triple therapy, STT) for 7 days (86.8%). The eradication rates varied with regimens, being 73% in STT, 81.8% in bismuth-based quadruple therapy, 100% in sequential therapy, and 90.3% in concomitant therapy. The eradication rate in treatment-naïve patients was higher than that in patients previously treated for H. pylori infection (73.8% vs. 58.5%, P < 0.001). The overall eradication rate for second-line therapy was 84.3%. There was no statistical difference in eradication rates among various regimens. H. pylori eradication rate using STT is decreasing in Korea and has become sub-optimal, suggesting the need for alternative regimens to improve the efficacy of first-line therapy for H. pylori infection.

KEYWORDS:

Eradication Success; First-line Therapy; Helicobacter pylori; On-line Registry

PMID:
27478335
PMCID:
PMC4951554
DOI:
10.3346/jkms.2016.31.8.1246
[Indexed for MEDLINE]
Free PMC Article

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