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Clin Oral Investig. 2017 Mar;21(2):533-540. doi: 10.1007/s00784-016-1905-1. Epub 2016 Aug 1.

Erosion protection benefits of stabilized SnF2 dentifrice versus an arginine-sodium monofluorophosphate dentifrice: results from in vitro and in situ clinical studies.

Author information

1
School of Oral and Dental Sciences, Bristol Dental School and Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK. N.X.West@bristol.ac.uk.
2
Procter and Gamble, Cincinnati, OH, USA.
3
School of Oral and Dental Sciences, Bristol Dental School and Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK.

Abstract

OBJECTIVES:

The aim of these investigations was to assess the ability of two fluoride dentifrices to protect against the initiation and progression of dental erosion using a predictive in vitro erosion cycling model and a human in situ erosion prevention clinical trial for verification of effectiveness.

MATERIALS AND METHODS:

A stabilized stannous fluoride (SnF2) dentifrice (0.454 % SnF2 + 0.077 % sodium fluoride [NaF]; total F = 1450 ppm F) [dentifrice A] and a sodium monofluorophosphate [SMFP]/arginine dentifrice (1.1 % SMFP + 1.5 % arginine; total F = 1450 ppm F) [dentifrice B] were tested in a 5-day in vitro erosion cycling model and a 10-day randomized, controlled, double-blind, two-treatment, four-period crossover in situ clinical trial. In each study, human enamel specimens were exposed to repetitive product treatments using a standardized dilution of test products followed by erosive acid challenges in a systematic fashion.

RESULTS:

Both studies demonstrated statistically significant differences between the two products, with dentifrice A providing significantly better enamel protection in each study. In vitro, dentifrice A provided a 75.8 % benefit over dentifrice B (p < 0.05, ANOVA), while after 10 days in the in situ model, dentifrice A provided 93.9 % greater protection versus dentifrice B (p < 0.0001, general linear mixed model).

CONCLUSION:

These results support the superiority of stabilized SnF2 dentifrices for protecting human teeth against the initiation and progression of dental erosion.

CLINICAL RELEVANCE:

Stabilized SnF2 dentifrices may provide more significant benefits to consumers than conventional fluoride dentifrices.

KEYWORDS:

Clinical trial; Dentifrice; Erosion; Tooth wear

PMID:
27477786
PMCID:
PMC5318474
DOI:
10.1007/s00784-016-1905-1
[Indexed for MEDLINE]
Free PMC Article

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