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J Laryngol Otol. 2016 Sep;130(9):811-5. doi: 10.1017/S0022215116008598. Epub 2016 Aug 1.

Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial.

Author information

1
Department of Otolaryngology,Khon Kaen Hospital,Thailand.
2
Department of Medical Technology,Khon Kaen Hospital,Thailand.
3
Department of Otorhinolaryngology,Faculty of Medicine,Khon Kaen University,Thailand.

Abstract

OBJECTIVES:

To compare the clinical effectiveness and adverse events for 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in the treatment of otomycosis.

METHODS:

A total of 120 otomycosis patients were randomly assigned to receive either 1 per cent clotrimazole solution (intervention group) or 3 per cent boric acid in 70 per cent alcohol (control group) at the Khon Kaen Hospital ENT out-patient department. Treatment effectiveness was determined based on the otomicroscopic absence of fungus one week after therapy, following a single application of treatment.

RESULTS:

After 1 week of treatment, there were data for 109 participants, 54 in the clotrimazole group and 55 in the boric acid group. The absolute difference in cure rates between 1 per cent clotrimazole solution and 3 per cent boric acid in 70 per cent alcohol was 17.9 per cent (95 per cent confidence interval, 2.3 to 33.5; p = 0.028) and the number needed to treat was 6 (95 per cent confidence interval, 3.0 to 43.4). Adverse events for the two agents were comparable.

CONCLUSION:

One per cent clotrimazole solution is more effective than 3 per cent boric acid in 70 per cent alcohol for otomycosis treatment.

KEYWORDS:

Antifungal Agents; Boric Acids; Clotrimazole; Mycoses; Otitis Externa; Otomycosis

PMID:
27477534
DOI:
10.1017/S0022215116008598
[Indexed for MEDLINE]

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