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Intern Med. 2016;55(15):2105-8. doi: 10.2169/internalmedicine.55.4655. Epub 2016 Aug 1.

Systemic Inflammatory Syndrome Associated with a Case of Jugular Paraganglioma.

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Department of General Internal Medicine, Hiroshima University Hospital, Japan.


Jugular paraganlioma is a benign, slow-growing tumor originating from the paraganglion cells and it is associated with catecholamine secretion. Paragangliomas can secrete Interleukin-6 (IL-6) and present as a systemic inflammatory syndrome; these characteristics have not been previously associated with jugular paragangliomas. A 63-year-old man with a jugular tumor in the skull base was referred to our hospital for an evaluation of pyrexia, back pain, and acute inflammation. His serum IL-6 level was elevated on admission and it decreased after radiotherapy. This is the first known case of a jugular paraganglioma exhibiting systemic inflammatory syndrome.

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