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Neuron. 2016 Jul 20;91(2):213-5. doi: 10.1016/j.neuron.2016.07.011.

A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics.

Author information

1
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
2
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dsb@seas.upenn.edu.

Abstract

In this issue of Neuron, Grayson et al. (2016) report how inhibition of amygdala impacts amygdalocortical and corticocortical functional connectivity. Their study predicts changes in functional brain topology, induced by pharmacologic modulation of neuroanatomical circuits using designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of amygdala in structural brain networks.

KEYWORDS:

DREADDs; functional brain network; network neuroscience; structural brain network; virtual lesioning

PMID:
27477013
DOI:
10.1016/j.neuron.2016.07.011
[Indexed for MEDLINE]
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