Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma

Kalijn F Bol; Thomas van den Bosch; Gerty Schreibelt; Hanneke W Mensink; Jan E E Keunen; Emine Kiliç; Wouter J Japing; Kaspar W Geul; Harm Westdorp; Steve Boudewijns; Sandra A J Croockewit; Michelle M van Rossum; Anna L de Goede; Nicole C Naus; Winette T A van der Graaf; Winald R Gerritsen; Annelies de Klein; Cornelis J A Punt; Carl G Figdor; Victoria M Cohen; Dion Paridaens; I Jolanda M de Vries

doi:10.1016/j.ophtha.2016.06.027

Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma

Ophthalmology. 2016 Oct;123(10):2265-7. doi: 10.1016/j.ophtha.2016.06.027. Epub 2016 Jul 29.

Authors

Kalijn F Bol¹, Thomas van den Bosch², Gerty Schreibelt³, Hanneke W Mensink⁴, Jan E E Keunen⁵, Emine Kiliç⁶, Wouter J Japing⁷, Kaspar W Geul⁸, Harm Westdorp¹, Steve Boudewijns¹, Sandra A J Croockewit⁹, Michelle M van Rossum¹⁰, Anna L de Goede¹¹, Nicole C Naus⁶, Winette T A van der Graaf¹², Winald R Gerritsen¹³, Annelies de Klein¹⁴, Cornelis J A Punt¹⁵, Carl G Figdor³, Victoria M Cohen¹⁶, Dion Paridaens¹⁷, I Jolanda M de Vries¹⁸

Affiliations

¹ Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands; Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.
² Department of Ocular Oncology, Rotterdam Eye Hospital, Rotterdam, The Netherlands.
³ Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
⁴ Department of Ocular Oncology, Rotterdam Eye Hospital, Rotterdam, The Netherlands; Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.
⁵ Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁶ Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands.
⁷ Department of Ophthalmology, University Medical Center Groningen, Groningen, The Netherlands.
⁸ Department of Internal Medicine, Sint Franciscus Hospital, Rotterdam, The Netherlands.
⁹ Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands.
¹⁰ Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
¹¹ Department of Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands.
¹² Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Medical Oncology, The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, United Kingdom.
¹³ Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.
¹⁴ Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.
¹⁵ Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands.
¹⁶ Department of Ophthalmology, Moorfields Eye Hospital and St. Bartholomew's Hospital, London, United Kingdom.
¹⁷ Department of Ocular Oncology, Rotterdam Eye Hospital, Rotterdam, The Netherlands; Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands.
¹⁸ Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands; Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: Jolanda.deVries@radboudumc.nl.

PMID: 27476772
DOI: 10.1016/j.ophtha.2016.06.027

No abstract available

Publication types

Clinical Trial
Clinical Trial, Phase II
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
CD8-Positive T-Lymphocytes / immunology
Cancer Vaccines / administration & dosage*
Dendritic Cells / immunology*
Disease-Free Survival
Female
Humans
Male
Melanoma / immunology
Melanoma / mortality
Melanoma / pathology
Melanoma / therapy*
Middle Aged
Monophenol Monooxygenase / immunology
Survival Rate
Uveal Neoplasms / immunology
Uveal Neoplasms / mortality
Uveal Neoplasms / pathology
Uveal Neoplasms / therapy*
Vaccination*
gp100 Melanoma Antigen / immunology

Substances

Cancer Vaccines
gp100 Melanoma Antigen
Monophenol Monooxygenase

Supplementary concepts

Uveal melanoma