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Clin Chim Acta. 2016 Oct 1;461:61-8. doi: 10.1016/j.cca.2016.07.021. Epub 2016 Jul 28.

Differences in microbial metabolites in urine headspace of subjects with Immune Thrombocytopenia (ITP) detected by volatile organic compound (VOC) analysis and metabolomics.

Author information

1
Dept. Life, Health & Chemical Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, United Kingdom.
2
Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL, United Kingdom.
3
Gastroenterology Research Dept., Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
4
Dept. of Haematology, Addenbrooke's Hospital, Cambridge, CB2 2QQ, United Kingdom.

Abstract

ITP is an organ-specific autoimmune disorder characterised by a low platelet count whose cause is uncertain. A possible factor is food intolerance, although much of the information linking this with ITP is anecdotal. The role of food intolerance in ITP was studied by replacing a normal diet with an elemental diet (E028), but this did not increase platelet counts. Clear differences, however, were apparent between the volatile organic compounds (VOCs) in the urine headspace of patients with ITP and those present in healthy volunteers, which leads to speculation that abnormal metabolic activity of the intestinal microbiome may be a factor causing ITP. However, further work is needed to confirm this. There were also differences between the VOCs of patients on a normal diet and those on the elemental diet, and in this case, the VOCs involved are very likely to be of bacterial origin, as their production is affected by dietary manipulation. Many of these VOCs are known to be toxic.

KEYWORDS:

ITP; Immune Thrombocytopenia; Metabolomics; Selective ion flow tube mass spectrometry (SIFT-MS); VOCs; Volatile organic compounds

PMID:
27475979
DOI:
10.1016/j.cca.2016.07.021
[Indexed for MEDLINE]

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