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EBioMedicine. 2016 Sep;11:165-172. doi: 10.1016/j.ebiom.2016.07.028. Epub 2016 Jul 25.

Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization.

Author information

1
Division of Oral Medicine and Pathology, University Hospital of Trieste, Piazza dell'Ospitale 1, 34129 Trieste, Italy; Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
2
Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
3
Cellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
4
Department of Medical, Surgical and Health Sciences, University Hospital of Trieste, Strada di Fiume, 447, 34149 Trieste, Italy.
5
Division of Oral Medicine and Pathology, University Hospital of Trieste, Piazza dell'Ospitale 1, 34129 Trieste, Italy.
6
Department of Medical, Surgical and Health Sciences, University Hospital of Trieste, Strada di Fiume, 447, 34149 Trieste, Italy; Molecular Medicine, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
7
Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University Hospital of Trieste, Strada di Fiume, 447, 34149 Trieste, Italy. Electronic address: zacchign@icgeb.org.

Abstract

Laser therapy, recently renamed as photobiomodulation, stands as a promising supportive treatment for oral mucositis induced by oncological therapies. However, its mechanisms of action and, more importantly, its safety in cancer patients, are still unclear. Here we explored the anti-cancer effect of 3 laser protocols, set at the most commonly used wavelengths, in B16F10 melanoma and oral carcinogenesis mouse models. While laser light increased cell metabolism in cultured cells, the in vivo outcome was reduced tumor progression. This striking, unexpected result, was paralleled by the recruitment of immune cells, in particular T lymphocytes and dendritic cells, which secreted type I interferons. Laser light also reduced the number of highly angiogenic macrophages within the tumor mass and promoted vessel normalization, an emerging strategy to control tumor progression. Collectively, these results set photobiomodulation as a safety procedure in oncological patients and open the way to its innovative use for cancer therapy.

PMID:
27475897
PMCID:
PMC5049921
DOI:
10.1016/j.ebiom.2016.07.028
[Indexed for MEDLINE]
Free PMC Article

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