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Trends Microbiol. 2016 Nov;24(11):872-886. doi: 10.1016/j.tim.2016.06.012. Epub 2016 Jul 26.

Host-Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization.

Author information

1
Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
2
Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Electronic address: rachel.mcloughlin@tcd.ie.

Abstract

Staphylococcus aureus persistently colonizes the anterior nares of approximately one fifth of the population and nasal carriage is a significant risk factor for infection. Recent advances have significantly refined our understanding of S. aureus-host communication during nasal colonization. Novel bacterial adherence mechanisms in the nasal epithelium have been identified, and novel roles for both the innate and the adaptive immune response in controlling S. aureus nasal colonization have been defined, through the use of both human and rodent models. It is clear that S. aureus maintains a unique, complex relationship with the host immune system and that S. aureus nasal colonization is overall a multifactorial process which is as yet incompletely understood.

KEYWORDS:

Staphylococcus aureus; nasal colonization

PMID:
27474529
DOI:
10.1016/j.tim.2016.06.012
[Indexed for MEDLINE]

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