Format

Send to

Choose Destination
Reprod Toxicol. 2016 Oct;65:170-178. doi: 10.1016/j.reprotox.2016.07.016. Epub 2016 Jul 26.

Autism spectrum disorder and prenatal exposure to selective serotonin reuptake inhibitors: A systematic review and meta-analysis.

Author information

1
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Canada; Division of Research Planning, Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, Japan.
2
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Canada; Department of Emergency Medicine, Kyoto Prefectural University of Medicine, Japan.
3
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Canada.
4
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Canada; Motherisk Program, The Hospital for Sick Children, Canada. Electronic address: shinya.ito@sickkids.ca.

Abstract

To obtain the risk estimates of autism spectrum disorder (ASD) in the offspring exposed to serotonin reuptake inhibitors (SSRI) in utero, we performed systematic review and meta-analysis of relevant studies. Five case-control and three cohort studies were eligible for the analysis. The SSRI group had significantly higher risk of ASD than the SSRI non-exposed group (pooled OR 1.45, 95% CI 1.15-1.82). In the subgroup analyses, however, the risk of ASD was similar between the SSRI group and other antidepressants group (pooled OR 1.14, 95% CI 0.67-1.96). Furthermore, when the analysis was confined to those born to the women with psychiatric disorders, the SSRI group did not show an increased ASD risk (pooled OR 0.96, 95% CI 0.57-1.63) compared to non-exposed groups. In conclusion, SSRI use in pregnancy is associated with an increased risk of ASD in the offspring, but maternal psychiatric condition is a major confounding factor.

KEYWORDS:

Autism spectrum disorder; Child; Meta-analysis; Prenatal exposure delayed effect; Serotonin reuptake inhibitors

PMID:
27474253
DOI:
10.1016/j.reprotox.2016.07.016
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center