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Enferm Infecc Microbiol Clin. 2016 Jul;34 Suppl 3:47-51. doi: 10.1016/S0213-005X(16)30219-1.

[Management and treatment of patients with hepatitis B].

[Article in Spanish]

Author information

Unidad VIH, Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España. Electronic address:
Servicio de Hepatología-Medicina Interna, Hospital Universitari Vall d'Hebron, Barcelona, España.


Chronic hepatitis B is a major cause of morbidity and mortality worldwide. Approximately one third of the world's population has serological evidence of past or present infection by hepatitis B virus (HBV) and 350-400 million people are chronic HBV surface antigen carriers. The aim of therapy is to prevent the onset of liver fibrosis and development of cirrhosis or hepatocarcinoma by sustained suppression of viral replication. Currently there are 2 strategies for the treatment of chronic hepatitis B: the pegylated interferon and long-term treatment with nucleoside/nucleotide analogues. Pegylated interferon has the advantage of being a treatment of limited duration, and is particularly suitable for patients with chronic hepatitis with positive HBeAg (hepatitis B e antigen), but the unfavorable adverse event profile and route of parenteral administration makes it less used than nucleoside/nucleotide analogues. Tenofovir and entecavir have shown to be potent inhibitors of HBV with a high genetic barrier to resistance and few adverse effects, so are considered as the first line therapy.


Carcinoma hepatocelular; Chronic hepatitis B; Cirrosis hepática; Entecavir; Hepatitis B crónica; Hepatocellular carcinoma; Inferferon; Interferón; Liver cirrhosis; Tenofovir; Tratamiento; Treatment

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