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Nutr Cancer. 2016 Oct;68(7):1083-96. doi: 10.1080/01635581.2016.1206579. Epub 2016 Jul 29.

Lycopene Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies.

Author information

  • 1a Department of General Surgery , Xiangya Hospital of Central South University , Changsha , China.
  • 2b Department of Physiology , Xiangya School of Medical Central South University , Changsha , China.
  • 3c Department of Psychology , The Second Artillery General Hospital, PLA . Beijing , China.
  • 4d Department of Science and Education , The First People's Hospital of Changde City , Changde , China.
  • 5e Department of General Surgery , Xiangya Hospital of Central South University , Changsha , China.

Abstract

A number of epidemiological studies have explored the association between lycopene or lycopene-rich food intake and the risk of colorectal cancer, but the results of these studies have not been consistent. We conducted a systematic review and meta-analysis of studies published in the PubMed and EMBASE databases to quantitatively assess the association between lycopene consumption and the risk of colorectal cancer. A total of 15 studies were included in the meta-analysis, and the summary relative risk (RR) for highest versus lowest category indicated no significant association between lycopene consumption and the risk of colorectal cancer [RR = 0.94, 95% confidence interval (CI): 0.80-1.10]. However, a significant inverse association was observed between lycopene consumption and the site of cancer in the colon (RR = 0.88, 95% CI: 0.81-0.96). We also found that the incidence of colon cancer and lycopene intake did not exhibit dose-response relationships. The Grades of Recommendations Assessment, Development and Evaluation (GRADE) quality in our study was very low. In conclusion, this meta-analysis indicates that lycopene consumption is not associated with the risk of colorectal cancer. Further research will be needed in this area to provide conclusive evidence.

PMID:
27472298
DOI:
10.1080/01635581.2016.1206579
[PubMed - in process]
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