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PLoS Genet. 2016 Jul 29;12(7):e1006223. doi: 10.1371/journal.pgen.1006223. eCollection 2016 Jul.

Exposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function.

Author information

1
Molecular Toxicology Inter-departmental Program, University of California, Los Angeles, Los Angeles, California, United States of America.
2
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America.
3
Department of Environmental Health Sciences, University of California, Los Angeles, Los Angeles, California, United States of America.
4
Institute for Society and Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.
5
Department of Biostatistics, University of California, Los Angeles, Los Angeles, California, United States of America.

Abstract

Concerns about the safety of Bisphenol A, a chemical found in plastics, receipts, food packaging and more, have led to its replacement with substitutes now found in a multitude of consumer products. However, several popular BPA-free alternatives, such as Bisphenol S, share a high degree of structural similarity with BPA, suggesting that these substitutes may disrupt similar developmental and reproductive pathways. We compared the effects of BPA and BPS on germline and reproductive functions using the genetic model system Caenorhabditis elegans. We found that, similarly to BPA, BPS caused severe reproductive defects including germline apoptosis and embryonic lethality. However, meiotic recombination, targeted gene expression, whole transcriptome and ontology analyses as well as ToxCast data mining all indicate that these effects are partly achieved via mechanisms distinct from BPAs. These findings therefore raise new concerns about the safety of BPA alternatives and the risk associated with human exposure to mixtures.

PMID:
27472198
PMCID:
PMC4966967
DOI:
10.1371/journal.pgen.1006223
[Indexed for MEDLINE]
Free PMC Article

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