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Biomed Pharmacother. 2016 Aug;82:555-60. doi: 10.1016/j.biopha.2016.05.038. Epub 2016 Jun 6.

Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells.

Author information

1
Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Laboratório de Imunogenética, CEP 50670-420, Recife, PE, Brazil. Electronic address: thiago.andre.ufpe@gmail.com.
2
Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Laboratório de Imunogenética, CEP 50670-420, Recife, PE, Brazil. Electronic address: acllb2003@yahoo.com.br.
3
Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, CEP 50740-520, Recife, PE, Brazil.
4
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, CEP 40296-710, Salvador, BA, Brazil.
5
Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Laboratório de Imunogenética, CEP 50670-420, Recife, PE, Brazil. Electronic address: valeria@cpqam.fiocruz.br.

Abstract

Cancer remains a high incidence and mortality disease, causing around 8.2 million of deaths in the last year. Current chemotherapy needs to be expanded, making research for new drugs a necessary task. Immune system modulation is an emerging concept in cancer cell proliferation control. In fact, there are a number of mechanisms underlying the role immune system plays in tumor cells. In this work, we describe the structural design, synthesis, antitumor and immunomodulatory potential of 31 new 1,3-thiazole and thiosemicarbazone compounds. Cisplatin was used as anticancer drug control. Cytotoxicity against J774A.1 macrophages and antitumor activity against HT-29 and Jurkat cells was determined. These 1,3-thiazole and thiosemicarbazone compounds not only exhibited cytotoxicity in cancer cells, but were able to cause irreversible cancer cell damage by inducing necrosis and apoptosis. In addition, these compounds, especially pyridyl-thiazoles compounds, regulated immune factors such as interleukin 10 and tumor necrosis factor, possible by directing immune system in favor of modulating cancer cell proliferation. By examining their pharmacological activity, we were able to identify new potent and selective anticancer compounds.

KEYWORDS:

1,3-thiazoles; Cancer; Cell death; Drug development; Immune system; Thiosemicarbazones

PMID:
27470396
DOI:
10.1016/j.biopha.2016.05.038
[Indexed for MEDLINE]

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